Publications

This is home for my research publications, each linked with
accompanying preprints, posters, and/or news pieces.

Comparison of different definitions of traumatic brain injury: implications for cohort characteristics and survival in women, Philadelphia, USA

EHR study describing different definitions for Traumatic Brain Injury (TBI) and re-examining them to provide an expanded definition able to better characterize TBI among female patients.
Research
EHR
TBI
May 27, 2024
Bernadette A. D’Alonzo, Abigail C. Bretzin, Andrea L.C. Schneider, Rebecca B. Morse, Silvia P. Canelón, Doug J. Wiebe, Mary Regina Boland

A medication-wide association study (MWAS) on repurposed drugs for COVID-19 with Pre-pandemic prescription medication exposure and pregnancy outcomes

EHR study describing an MWAS approach to explore connections between exposure to repurposed COVID-19 prescription medications and the risk of cesarean section, preterm birth, and stillbirth
Research
covid-19
EHR
pregnancy
medications
Nov 24, 2022
Lena Davidson, Silvia P. Canelón, Mary Regina Boland

Ten simple rules to host an inclusive conference

Community-led publication describing ten guidelines for hosting an inclusive conference
Education
community
Jul 21, 2022
Rocío Joo, Andrea Sánchez-Tapia, Sara Mortara, Yanina Bellini Saibene, Heather Turner, Dorothea Hug Peter, Natalia Soledad Morandeira, Matt Bannert, Batool Almazrouq, Elizabeth Hare, Laura Ación, Juan Pablo Narváez-Gómez, Marcela Alfaro Córdoba, Federico Marini, Rita Giordano, Silvia Canelón, Anicet Ebou, Adithi R. Upadhya, Joselyn Chávez, Janani Ravi

Medication-Wide Association Study Using Electronic Health Record Data of Prescription Medication Exposure and Multifetal Pregnancies: Retrospective Study

EHR study describing an MWAS approach to explore connections between prescription medication exposure and the risk of multiple gestation pregnancies
Research
EHR
pregnancy
medications
Jun 7, 2022
Lena Davidson, Silvia P. Canelón, Mary Regina Boland

Design and Evaluation of a Postpartum Depression Ontology

Study describing an ontology created for the identification of patients with postpartum depression.
Research
EHR
pregnancy
ppd
Mar 9, 2022
Rebecca B. Morse, Abigail C. Bretzin, Silvia P. Canelón, Bernadette A. D’Alonzo, Andrea L. C. Schneider, Mary R. Boland

Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait

Retrospective cohort study finding both sickle cell trait and disease to be associated with an increased risk of stillbirth, suggesting that sickle cell carriers would benefit from additional risk assessment during pregnancy.
Research
EHR
pregnancy
sickle cell disease
Nov 24, 2021
Silvia P. Canelón, Samantha Butts, Mary Regina Boland

Harnessing electronic health records to study emerging environmental disasters: a proof of concept with perfluoroalkyl substances (PFAS)

Proof-of-concept study detailing how Electronic Health Record (EHR) data can be leveraged to study the impacts of environmental disasters like widespread exposure to perfluoroalkyl substances (PFAS).
Research
environment
EHR
PFAS
Aug 11, 2021
Mary Regina Boland, Lena M. Davidson, Silvia P. Canelón, Jessica Meeker, Trevor Penning, John H. Holmes, Jason H. Moore

A Bayesian Hierarchical Modeling Framework for Geospatial Analysis of Adverse Pregnancy Outcomes

Study describing a Bayesian hierarchichal modeling framework used to explore which neighborhood-level factors and patient-level features were most informative for preterm birth and stillbirth pregnancy outcomes.
Research
pregnancy
health disparities
EHR
preprint
May 11, 2021
Cecilia Balocchi, Ray Bai, Jessica Liu, Silvia P. Canelón, Edward I. George, Yong Chen, Mary Regina Boland

Individual-Level and Neighborhood-Level Risk Factors for Severe Maternal Morbidity

Study showing that neighborhood-level risk factors are independent predictors of Severe Maternal Morbidity, providing further evidence that racial disparities in maternal outcomes are symptoms of historical and structural racism.
Research
pregnancy
health disparities
EHR
Apr 8, 2021
Jessica R. Meeker, Silvia P. Canelón, Ray Bai, Lisa D. Levine, Mary Regina Boland

Not All C-sections Are the Same: Investigating Emergency vs. Elective C-section Deliveries as an Adverse Pregnancy Outcome

Publication and poster accepted for the 2021 Pacific Biocomputing Symposium. This study utilizes Electronic Health Record (EHR) data to assess the impact of pregnancy-specific maternal morbidity and patient-specific characteristics on experiencing an emergency admission at the time of delivery and its relationship to Cesarean section (C-section) deliveries
Research
pregnancy
PSB
EHR
Dec 10, 2020
Silvia P. Canelón, Mary Regina Boland

Development and Evaluation of MADDIE: Method to Acquire Delivery Date Information from Electronic Health Records

An R algorithm designed to extract delivery episode details from structured Electronic Health Record data.
Research
Nov 17, 2020
Silvia P. Canelón, Heather H. Burris, Lisa D. Levine, Mary Regina Boland

Is Hydroxychloroquine Safe During Pregnancy? Observations from Penn Medicine

Preprint as a contribution from a rapid response exploration of hydroxychloroquine effects on pregnancy-related outcomes
Research
EHR
covid-19
medications
pregnancy
preprint
May 6, 2020
Lena Davidson, Silvia P. Canelón, Mary Regina Boland

A Systematic Literature Review of Factors Affecting the Timing of Menarche: The Potential for Climate Change to Impact Women’s Health

Review paper highlighting how climate change could impact the timing of first menstruation and increase the burden of disease.
Research
climate change
menstruation
Mar 5, 2020
Silvia P. Canelón, Mary Regina Boland

Investigating Pregnancy-Related Health Outcomes Among Patients with Sickle Cell Disease and Linking with Health Disparities

Poster presented at the 2019 American Medical Informatics Association Annual Symposium held November 16th-20th in Washington D.C.
Research
pregnancy
AMIA
EHR
sickle cell disease
Nov 20, 2019
Silvia P. Canelón, Mary Regina Boland

Substrate Strain Mitigates Effects of β-Aminopropionitrile-Induced Reduction in Enzymatic Crosslinking

Research highlighting how the effects of BAPN on type I collagen, produced by osteoblasts, were mitigated by mechanical loading.
Research
osteoblasts
Type I collagen
BAPN
AFM
crosslinking
mechanical loading
Sep 3, 2019
Silvia P. Canelón, Joseph M. Wallace

Characterization of Type I Collagen and Osteoblast Response to Mechanical Loading

Dissertation completed as part of the requirements for a doctorate degree in Biomedical Engineering.
Research
osteoblasts
Type I collagen
BAPN
AFM
crosslinking
mechanical loading
May 1, 2018
Silvia P. Canelón

β-Aminopropionitrile-Induced Reduction in Enzymatic Crosslinking Causes In Vitro Changes in Collagen Morphology and Molecular Composition

Publication highlighting how a reduction in enzymatic crosslinking alters type I collagen morphology through an increase in D-spacing.
Research
osteoblasts
Type I collagen
BAPN
AFM
crosslinking
Nov 6, 2016
Silvia P. Canelón, Joseph M. Wallace
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